用于筛查轻度认知障碍的古巴版修订版Addenbrooke认知检查的验证
Validation of the Cuban Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Cognitive Impairment.
作者信息
Broche-Pérez Yunier, López-Pujol Héctor Alejandro
出版信息
Dement Geriatr Cogn Disord. 2017;44(5-6):320-327. doi: 10.1159/000481345. Epub 2018 Jan 30.
BACKGROUND/AIMS: The diagnostic accuracy of the Cuban version of the revised Addenbrooke's Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI) in comparison with the Mini-Mental State Examination (MMSE) was assessed.
METHODS
The Cuban ACE-R was administered to a group of 129 elderly subjects (92 cognitively healthy and 37 subjects with MCI). The t tests for independent samples were used to compare scores of different psychometric scales between groups, and effect sizes (Cohen's d) were calculated. Cronbach's coefficient α was used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for MCI was assessed by receiver operating characteristic (ROC) curves.
RESULTS
The Cuban ACE-R had reliable internal consistency (Cronbach's coefficient α = 0. 879). The optimal cut-off score for ACE-R for detecting MCI was 84/85. The sensitivity and specificity of ACE-R to screen for MCI was superior to those of MMSE. The area under the ROC curve of the Cuban ACE-R was much larger than that of MMSE (0.93 and 0.63) for detecting MCI.
CONCLUSION
The Cuban ACE-R is a valid screening tool for detecting cognitive impairment. It is more sensitive and accurate in screening for MCI than MMSE.
背景/目的：评估古巴版修订的Addenbrooke认知检查量表（ACE-R）与简易精神状态检查表（MMSE）相比，在识别轻度认知障碍（MCI）方面的诊断准确性。
方法
对129名老年受试者（92名认知健康者和37名MCI患者）进行古巴版ACE-R测试。采用独立样本t检验比较两组不同心理测量量表的得分，并计算效应量（Cohen's d）。用Cronbach's系数α评估心理测量量表的信度。通过受试者工作特征（ROC）曲线评估ACE-R筛查MCI的效度。
结果
古巴版ACE-R具有可靠的内部一致性（Cronbach's系数α = 0.879）。ACE-R检测MCI的最佳截断分数为84/85。ACE-R筛查MCI的敏感性和特异性优于MMSE。古巴版ACE-R检测MCI的ROC曲线下面积远大于MMSE（分别为0.93和0.63）。
结论
古巴版ACE-R是检测认知障碍的有效筛查工具。在筛查MCI方面，它比MMSE更敏感、准确。
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