验证 Addenbrooke's 认知测验 III 在日本检测轻度认知障碍和痴呆的有效性。
Validation of Addenbrooke's cognitive examination III for detecting mild cognitive impairment and dementia in Japan.
机构信息
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
出版信息
BMC Geriatr. 2019 Apr 29;19(1):123. doi: 10.1186/s12877-019-1120-4.
BACKGROUND
Early detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation. We investigated the screening accuracy of the Japanese version of Addenbrooke's Cognitive Examination III (ACE-III) to diagnose MCI and dementia.
METHODS
The original ACE-III was translated and adapted to Japanese. It was then administered to a Japanese population. The Hasegawa Dementia Scale-revised (HDS-R) and Mini-mental State Examination (MMSE) were also applied to evaluate cognitive dysfunction. In total, 389 subjects (dementia = 178, MCI = 137, controls = 73) took part in our study.
RESULTS
The optimal ACE-III cut-off scores to detect MCI and dementia were 88/89 (sensitivity 0.77, specificity 0.92) and 75/76 (sensitivity 0.82, specificity 0.90), respectively. ACE-III was superior to HDS-R and MMSE in the detection of MCI or dementia. The internal consistency, test-retest reliability, and inter-rater reliability of ACE-III were excellent.
CONCLUSIONS
ACE-III is a useful cognitive test to detect MCI and dementia. ACE-III may be widely useful in clinical practice.
背景
早期发现轻度认知障碍（MCI）和痴呆症对于及时开始适当的治疗和防止疾病恶化非常重要。我们研究了 Addenbrooke 的认知测验第三版（ACE-III）日语版诊断 MCI 和痴呆症的筛查准确性。
方法
原始的 ACE-III 被翻译和改编为日语。然后在日本人群中进行了测试。还应用了长谷川痴呆量表修订版（HDS-R）和简易精神状态检查（MMSE）来评估认知功能障碍。共有 389 名受试者（痴呆=178，MCI=137，对照组=73）参加了我们的研究。
结果
用于检测 MCI 和痴呆症的最佳 ACE-III 截断分数分别为 88/89（敏感性 0.77，特异性 0.92）和 75/76（敏感性 0.82，特异性 0.90）。ACE-III 在检测 MCI 或痴呆症方面优于 HDS-R 和 MMSE。ACE-III 的内部一致性、重测信度和评分者间信度均非常优秀。
结论
ACE-III 是一种用于检测 MCI 和痴呆症的有用认知测验。ACE-III 在临床实践中可能具有广泛的应用价值。
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