Zeka Keti, Ruparelia Ketan C, Sansone Claudia, Macchiarelli Guido, Continenza Maria Adelaide, Arroo Randolph R J
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Skin Pharmacol Physiol. 2018;31(2):95-98. doi: 10.1159/000486135. Epub 2018 Feb 1.
Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extracted from saffron petals showed good biocompatibility with in vitro cultured fibroblasts. These new types of hydrogels may find applications in wound treatment and/or beautification.
藏红花提取物作为皮肤保护剂有着悠久的应用历史，这可能归因于它们清除自由基的能力。在这项工作中，测试了一种富含从藏红花（番红花）花瓣中分离出的抗氧化化合物的水凝胶的性能。这些水凝胶可被视为新型药物递送系统。水凝胶是交联聚合物网络，能吸收大量水分但保持固体性质，因此是敏感皮肤理想的敷料。我们在原代小鼠成纤维细胞上测试了富含抗氧化剂的水凝胶。富含从藏红花花瓣中提取的山奈酚和藏红花素的水凝胶与体外培养的成纤维细胞显示出良好的生物相容性。这些新型水凝胶可能在伤口治疗和/或美容方面找到应用。
