Departments of1Neurosurgery and.
Divisions of2Thoracic and Cardiovascular Surgery and.
J Neurosurg. 2019 Jan 1;130(1):302-311. doi: 10.3171/2017.8.JNS171103. Epub 2018 Feb 2.
Burr hole craniostomy is an effective and simple procedure for treating chronic subdural hematoma (CSDH). However, the surgical outcomes and recurrence of CSDH in patients with liver cirrhosis (LC) remain unknown. METHODS: A nationwide population-based cohort study was retrospectively conducted using data from the Taiwan National Health Insurance Research Database. The study included 29,163 patients who underwent first-time craniostomy for CSDH removal between January 1, 2001, and December 31, 2013. In total, 1223 patients with LC and 2446 matched non-LC control patients were eligible for analysis. All-cause mortality, surgical complications, repeat craniostomy, extended craniotomy, and long-term medical costs were analyzed. RESULTS: The in-hospital mortality rate (8.7% vs 3.1% for patients with LC and non-LC patients, respectively), frequency of hospital admission, length of ICU stay, number of blood transfusions, and medical expenditures of patients with LC who underwent craniostomy for CSDH were considerably higher than those of non-LC control patients. Patients with LC tended to require an extended craniotomy to remove subdural hematomas in the hospital or during long-term follow-up. The surgical outcome worsened with an increase in the severity of LC. CONCLUSIONS: Even for simple procedures following minor head trauma, LC remains a serious comorbidity with a poor prognosis.
颅骨钻孔术是治疗慢性硬脑膜下血肿(CSDH)的有效且简单的方法。然而,肝硬化(LC)患者行颅骨钻孔术治疗 CSDH 的手术结果和复发情况仍不清楚。
本研究采用台湾全民健康保险研究数据库中的数据,进行了一项全国性基于人群的回顾性队列研究。该研究共纳入 29163 例于 2001 年 1 月 1 日至 2013 年 12 月 31 日期间首次接受颅骨钻孔术治疗 CSDH 的患者。共有 1223 例 LC 患者和 2446 例匹配的非 LC 对照患者符合分析条件。分析了全因死亡率、手术并发症、再次颅骨钻孔术、扩大性颅骨切开术和长期医疗费用。
LC 患者的住院死亡率(8.7%比非 LC 患者的 3.1%)、住院次数、ICU 住院时间、输血次数和医疗费用均明显高于非 LC 对照患者。LC 患者在医院或长期随访期间行颅骨钻孔术治疗 CSDH 时,往往需要扩大性颅骨切开术来清除硬脑膜下血肿。LC 严重程度的增加使手术结果恶化。
即使对于轻微头部外伤后的简单手术,LC 仍然是一种严重的合并症,预后较差。