Emr Bryanna M, Alcamo Alicia M, Carcillo Joseph A, Aneja Rajesh K, Mollen Kevin P
1 Department of Surgery, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
2 Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC , Pittsburgh, Pennsylvania.
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):176-183. doi: 10.1089/sur.2017.316. Epub 2018 Feb 2.
Although there are some commonalities between pediatric and adult sepsis, there are important differences in pathophysiology, clinical presentation, and therapeutic approaches. The recognition and diagnosis of sepsis is a significant challenge in pediatric patients as vital sign aberrations and examination findings are often subtle as compared to those observed in adults. Gaps in knowledge that have been studied in depth in adult sepsis are still being investigated in pediatric patients such as best practices in ventilation, invasive monitoring, and resuscitation.
In this review, we address key differences in the etiology, presentation, resuscitation, and outcomes of sepsis in children compared with adults.
尽管儿童和成人脓毒症之间存在一些共性，但在病理生理学、临床表现和治疗方法上存在重要差异。脓毒症的识别和诊断在儿科患者中是一项重大挑战，因为与成人相比，生命体征异常和检查结果往往不明显。在成人脓毒症中已深入研究的知识空白，在儿科患者中仍在研究，如通气、侵入性监测和复苏的最佳实践。
在本综述中，我们阐述了儿童与成人脓毒症在病因、表现、复苏和结局方面的关键差异。
