Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Institute of Radiology, University Hospital Erlangen, Erlangen, Germany.
Med Phys. 2018 Apr;45(4):1586-1593. doi: 10.1002/mp.12785. Epub 2018 Mar 6.
To investigate the extent of MR image distortions in the pelvis caused by susceptibility-induced field inhomogeneities in MR images in the context of a study on MR-guided radiotherapy.
Using a high-bandwidth double-echo gradient echo sequence, field maps and distortion maps of the pelvis were calculated and evaluated for 219 exams (92 of female and 127 of male patients) to investigate patient-related image distortions caused by susceptibility differences in an ongoing study on MR-guided radiotherapy. The evaluation of distortions in the regions "rectum", "prostate", "cervix", and in a reference region in the gluteus maximus was based on masks drawn by two readers.
Distortions in the prostate and cervix were smaller than 0.03 px (0.1 mm) for 99% of voxels, and reached a maximum value of 0.09 px (0.3 mm). In the reference region, maximum distortions were smaller than in the prostate and cervix.
Using a geometric uncertainty of 0.2 px (0.6 mm) in margin definition for organs that are close to the rectum like the prostate and the cervix would be a cautious choice to account for susceptibility-induced distortions that can arise during MR-based treatment guidance for the imaging setting used in this study. Since distortions are inversely proportional to the readout bandwidth of the sequence, safety margins need to be adapted adequately. Additional sources of image distortions like gradient nonlinearities are not included in our margin recommendations and should be considered separately.
在一项关于磁共振引导放射治疗的研究中,调查盆腔磁共振图像中由于磁化率引起的磁场不均匀性导致的图像失真程度。
使用高带宽双回波梯度回波序列,计算并评估了 219 次检查(92 次女性和 127 次男性患者)的盆腔场图和失真图,以调查在一项关于磁共振引导放射治疗的研究中,由于磁化率差异引起的患者相关图像失真。在“直肠”、“前列腺”、“子宫颈”区域和臀大肌参考区域的失真评估是基于两位读者绘制的掩模进行的。
99%的体素中前列腺和子宫颈的失真小于 0.03 像素(0.1 毫米),最大失真值达到 0.09 像素(0.3 毫米)。在参考区域,最大失真小于前列腺和子宫颈。
在接近直肠的器官(如前列腺和子宫颈)的边缘定义中使用几何不确定性为 0.2 像素(0.6 毫米)是一个谨慎的选择,可以考虑到在本研究中使用的成像设置下,基于磁共振的治疗引导过程中可能出现的磁化率引起的失真。由于失真与序列的读出带宽成反比,因此需要适当调整安全裕度。我们的边缘建议不包括像梯度非线性这样的其他图像失真源,应单独考虑。