Noda Masaru, Tachibana Kazunoshin, Nakano Hiroshi, Abe Sadahiko, Murakami Yuko, Okano Maiko, Abe Noriko, Yoshida Sayaka, Kiko Yuichiro, Hashimoto Yuko, Ohtake Tohru
Dept. of Breast Surgery, Fukushima Medical University.
Gan To Kagaku Ryoho. 2017 Nov;44(12):1185-1187.
Mammary carcinoma with osteoclast-like giant cells is uncommon, and its onset mechanism and malignancy are unknown. We report a case of mammary carcinoma with osteoclast-like giant cells. A 41-year-old woman noticed a lump in her left breast. Ultrasound sonography findings suggested breast cancer. A core needle biopsy revealed invasive ductal carcinoma of the breast. Modified radicalmastectomy and sentinell ymph node biopsy were performed. Histopathologicalexamination revealed papillotubular carcinoma with osteoclast-like giant cells. Cells were positive for estrogen receptor and progesterone, and negative for HER2. MIB-1 index was under 5%. The giant cells were generally associated with an inflammatory, fibroblastic, hyper-vascular stroma. The carcinomatous part of the lesion was most frequently a well-to moderately differentiated invasive ductalcarcinoma. Immunohistochemicaland ultrastructuralstudies suggested that the osteoclast-like giant cells were of stromalhistiocytic origin. To understand biochemicalfindings of this carcinoma, more case studies are required to be reported.
伴有破骨细胞样巨细胞的乳腺癌并不常见，其发病机制和恶性程度尚不清楚。我们报告一例伴有破骨细胞样巨细胞的乳腺癌病例。一名41岁女性发现左乳有一肿块。超声检查结果提示乳腺癌。粗针活检显示为乳腺浸润性导管癌。行改良根治性乳房切除术和前哨淋巴结活检。组织病理学检查显示为伴有破骨细胞样巨细胞的乳头管状癌。细胞雌激素受体和孕激素阳性，HER2阴性。MIB-1指数低于5%。巨细胞通常与炎症性、成纤维细胞性、高血管性间质相关。病变的癌性部分最常见的是高分化至中分化浸润性导管癌。免疫组织化学和超微结构研究表明，破骨细胞样巨细胞起源于间质组织细胞。为了解这种癌的生化表现，需要报告更多的病例研究。
