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[一例采用雷莫西尤单抗和紫杉醇有效治疗的伴有腹膜播散的胃癌病例]

[A Case of Gastric Cancer with Peritoneal Dissemination Effectively Treated with Ramucirumab and Paclitaxel].

作者信息

Seo Shingo, Suzuki Takahisa, Misumi Toshihiro, Tashiro Hirotaka

机构信息

Dept. of Surgery, NHO Kure Medical Center and Chugoku Cancer Center.

出版信息

Gan To Kagaku Ryoho. 2017 Nov;44(12):1305-1307.

Abstract

A 66-year-old man was diagnosed with unresectable distal gastric cancer due to a locally advanced tumor and peritoneal dissemination. After gastrojejunostomy, he underwent S-1 plus cisplatin combination chemotherapy. After 2 courses of chemotherapy, weekly paclitaxel(PTX)was administered as second-line chemotherapy owing to tumor growth(PD). Although 4 courses of chemotherapy had been administered, he developed carcinomatous peritonitis and was hospitalized urgently. Despite diuretic therapy and drainage, the malignant ascites was not adequately controlled. However, he started ramucirumab (RAM)plus PTX chemotherapy as third-line therapy and ascites subsequently reduced, he regained oral intake and was discharged from hospital.

摘要

一名66岁男性因局部晚期肿瘤和腹膜播散被诊断为不可切除的远端胃癌。胃空肠吻合术后,他接受了S-1联合顺铂化疗。化疗2个疗程后,由于肿瘤进展(PD),每周给予紫杉醇(PTX)作为二线化疗。尽管已经进行了4个疗程的化疗,但他仍发生了癌性腹膜炎并紧急住院。尽管进行了利尿治疗和引流,但恶性腹水仍未得到充分控制。然而,他开始接受雷莫西尤单抗(RAM)联合PTX化疗作为三线治疗,腹水随后减少,他恢复了经口进食并出院。

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