Pina Lícia T S, Ferro Jamylle N S, Rabelo Thallita K, Oliveira Marlange A, Scotti Luciana, Scotti Marcus Tullius, Walker Cristiani Isabel Bandero, Barreto Emiliano O, Quintans Júnior Lucindo J, Guimarães Adriana G
a Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology , Federal University of Sergipe , Sergipe , Brazil.
b Multidisciplinary Research Center , Federal University of Alagoas , Maceió , Brazil.
Nat Prod Res. 2019 Jun;33(12):1773-1777. doi: 10.1080/14786419.2018.1434634. Epub 2018 Feb 2.
Allergic inflammation is a response of the body against pathogens by cytokine release and leucocyte recruitment. Recently, there was an increase in morbimortality associated with allergic inflammation, especially asthma. The treatment has many adverse effects, requiring the search for new therapies. Monoterpenes are natural products with anti-inflammatory activity demonstrated in several studies and can be an option to inflammation management. Thus, we investigated the effects of citronellol, α-terpineol and carvacrol on allergic inflammation. The model of asthma was established by OVA induction in male Swiss mice. The monoterpenes were administered (25, 50 or 100 mg/kg, i.p.) 1 h before induction. After 24hs, the animals were sacrificed to leucocytes and TNF-α quantification. Monoterpenes significantly decrease leucocyte migration and TNF-α levels, possibly by modulation of COX, PGE and H1 receptor, as demonstrated by molecular docking. These findings indicate that alcoholic monoterpenes can be an alternative for treatment of allergic inflammation and asthma.
过敏性炎症是机体通过细胞因子释放和白细胞募集对病原体作出的反应。最近，与过敏性炎症尤其是哮喘相关的病死人数有所增加。现有治疗方法存在许多不良反应，因此需要寻找新的治疗方法。单萜类化合物是在多项研究中已证实具有抗炎活性的天然产物，可能是炎症管理的一种选择。因此，我们研究了香茅醇、α-松油醇和香芹酚对过敏性炎症的影响。通过在雄性瑞士小鼠中用卵清蛋白诱导建立哮喘模型。在诱导前1小时腹腔注射单萜类化合物（25、50或100mg/kg）。24小时后，处死动物以对白细胞和肿瘤坏死因子-α进行定量分析。分子对接结果表明，单萜类化合物可能通过调节环氧化酶（COX）、前列腺素E（PGE）和组胺H1受体，显著减少白细胞迁移和肿瘤坏死因子-α水平。这些发现表明，单萜类醇可以作为治疗过敏性炎症和哮喘的替代药物。
