Jadus M R, Peck A B
Scand J Immunol. 1986 Jan;23(1):35-44. doi: 10.1111/j.1365-3083.1986.tb01940.x.
Immature monocytes residing in the spleens of newborn mice less than 6-7 days of age are known to suppress T-dependent and T-independent immune responses in vitro and in vivo. Suppression is mediated in part through products secreted by the newborn monocytes. In the present study, we have identified 3 monokines secreted by newborn, but not adult, monocytes correlating with materials possessing significant suppressor activity in vitro. These monokines have molecular weights of 58, 10.8, and 10 kilodaltons, appear to be proteins, and are insensitive to heat inactivation. The 58 kd material is antigenically distinct from alpha-fetoprotein, while the lower molecular weight materials are too large to be prostaglandins. Although these monokines can be shown to have activity in vitro, they are not as efficient as newborn monocytes in preventing alloreactivity in vivo.
已知存在于出生不到6至7天的新生小鼠脾脏中的未成熟单核细胞，在体外和体内均可抑制T细胞依赖性和非T细胞依赖性免疫反应。这种抑制作用部分是由新生单核细胞分泌的产物介导的。在本研究中，我们鉴定出3种由新生而非成年单核细胞分泌的单核因子，它们与体外具有显著抑制活性的物质相关。这些单核因子的分子量分别为58、10.8和10千道尔顿，似乎是蛋白质，并且对热失活不敏感。58 kd的物质在抗原性上与甲胎蛋白不同，而较低分子量的物质太大，不可能是前列腺素。尽管这些单核因子在体外可显示出活性，但在体内预防同种异体反应方面，它们不如新生单核细胞有效。
