在纤维蛋白存在的情况下，纤溶酶从谷氨酸纤溶酶原释放N端肽。
Release of N-terminal peptides from Glu-plasminogen by plasmin in the presence of fibrin.
作者信息
Takada A, Watahiki Y, Takada Y
出版信息
Thromb Res. 1986 Mar 15;41(6):819-27. doi: 10.1016/0049-3848(86)90380-4.
PMID:2939588
Abstract
The rate of plasmin-catalyzed Glu-plasminogen to Lys-plasminogen conversion was faster in the presence of fibrin than in its absence when assayed by SDS-polyacrylamide gel electrophoresis followed by quantification of stained bands by densitometer. Experiments with the isozymes Glu-plasminogen I and Glu-plasminogen II showed that plasmin-catalyzed formation of Lys-plasminogen II was especially facilitated in the presence of fibrin.
摘要
当通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳进行测定，随后用密度计对染色条带进行定量分析时，与不存在纤维蛋白的情况相比，在有纤维蛋白存在的情况下，纤溶酶催化谷氨酸型纤溶酶原向赖氨酸型纤溶酶原转化的速率更快。对同工酶谷氨酸型纤溶酶原I和谷氨酸型纤溶酶原II进行的实验表明，在有纤维蛋白存在的情况下，纤溶酶催化形成赖氨酸型纤溶酶原II的过程尤其容易。
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Release of N-terminal peptides from Glu-plasminogen by plasmin in the presence of fibrin.在纤维蛋白存在的情况下，纤溶酶从谷氨酸纤溶酶原释放N端肽。
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