比斯利1981年的论文：一项设计精良的队列研究对推动肝癌研究与预防的影响力。
Beasley's 1981 paper: The power of a well-designed cohort study to drive liver cancer research and prevention.
作者信息
Koshiol Jill, Liu Zhiwei, O'Brien Thomas R, Hildesheim Allan
机构信息
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, USA.
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, USA.
出版信息
Cancer Epidemiol. 2018 Apr;53:195-199. doi: 10.1016/j.canep.2018.01.007. Epub 2018 Feb 13.
The 1981 Lancet paper by Beasley et al., "Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan" is a seminal publication that clearly demonstrated that chronic infection with hepatitis B virus (HBV), as measured by seropositivity for the hepatitis B surface antigen (HBsAg), preceded the development of hepatocellular carcinoma (HCC). In doing so, this study paved the way for liver cancer prevention efforts through the implementation of hepatitis B vaccination programs. In this commentary, we will describe the discovery of HBV, which led to the study by Beasley et al.; summarize the major findings of the Beasley paper and its implications; discuss the importance of well-designed cohort studies for prevention activities; and consider the ramifications of the Beasley study and the work that has followed since.
比斯利等人于1981年发表在《柳叶刀》上的论文《肝细胞癌与乙型肝炎病毒。对台湾22707名男性的前瞻性研究》是一篇具有开创性的出版物，它清楚地表明，以乙型肝炎表面抗原（HBsAg）血清阳性来衡量的慢性乙型肝炎病毒（HBV）感染先于肝细胞癌（HCC）的发生。通过这样做，这项研究为通过实施乙肝疫苗接种计划来预防肝癌的努力铺平了道路。在这篇评论中，我们将描述导致比斯利等人开展此项研究的乙肝病毒的发现；总结比斯利论文的主要发现及其影响；讨论设计良好的队列研究对预防活动的重要性；并思考比斯利研究的影响以及此后所开展的工作。
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