Gavrilenkova V Iu, Selezneva V P, Runova V F, Kargina T M
Zh Mikrobiol Epidemiol Immunobiol. 1986 Mar(3):68-71.
Antitetanus immunoglobulin preparations with the increasing content of Fab-fragments (15, 30, 53%) have been obtained under specific experimental conditions. Tests for specific activity have revealed an insignificant decrease (13%) in this activity in the preparation containing 15% of Fab-fragments and its sharp drop in the preparations containing 30-50% of Fab-fragments. The specific activity of antitetanus immunoglobulin has been found to be related to the degree of its fragmentation.
在特定实验条件下，已获得Fab片段含量不断增加（15%、30%、53%）的抗破伤风免疫球蛋白制剂。特异性活性测试表明，含15%Fab片段的制剂中该活性仅有轻微下降（13%），而在含30 - 50%Fab片段的制剂中其活性急剧下降。已发现抗破伤风免疫球蛋白的特异性活性与其片段化程度有关。
