Barkhatova V P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(2):212-9.
The total and cerebral metabolism of catecholamines was studied in 134 patients with various extrapyramidal hyperkinetic syndromes. Homovanillic acid levels determined in the ventricular and lumbar cerebrospinal fluid served as an indicator of the cerebral metabolism of dopamine. In two patients with hepatocerebral dystrophy (HCD) and torsion dystonia the author studied the content of catecholamines in the cerebral tissue. This study showed a considerable increase in noradrenalin and dopamine levels in the striatum, which was more pronounced in cases of HCD. It has been concluded on the basis of the findings obtained that elevation of cerebral dopaminergic activity is one of characteristic biochemical signs of extrapyramidal hyperkineses. There was a significant increase in this activity following the destruction of the ventrolateral nucleus of the thalamus, which appears to be one of the biochemical mechanisms underlying an unfavourable effect of stereotaxic surgery for extrapyramidal hyperkineses. The importance of this pathology of noradrenergic systems in the pathogenesis of extrapyramidal diseases remains unclear and needs further investigation.
对134例患有各种锥体外系运动亢进综合征的患者进行了儿茶酚胺的整体及大脑代谢研究。测定脑室和腰椎脑脊液中的高香草酸水平作为多巴胺大脑代谢的指标。作者研究了2例患有肝脑变性（HCD）和扭转性肌张力障碍患者脑组织中的儿茶酚胺含量。该研究表明纹状体中去甲肾上腺素和多巴胺水平显著升高，在HCD患者中更为明显。基于所获得的研究结果得出结论，大脑多巴胺能活性升高是锥体外系运动亢进的特征性生化标志之一。丘脑腹外侧核破坏后该活性显著增加，这似乎是锥体外系运动亢进立体定向手术产生不良影响的生化机制之一。去甲肾上腺素能系统的这种病理改变在锥体外系疾病发病机制中的重要性仍不清楚，需要进一步研究。
