Mosunova T G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(10):1466-9.
The author examined the catecholamine metabolism in 78 children with polyetiological extrapyramidal lesions of the nervous system. Most of the cases were with the pallidnigral syndrome. A sharp drop in the catecholamine excretion, especially of the dopamine and DOPA were detected in the akinetico-rigid forms. In torsion muscular deformant dystonia there was the most expressed drop in the DOPA excretion. Under the impact of a pathogenetical treatment by L-DOPA in most of the cases there was an improvement of the clinical state and in the indices of the catecholamine metabolism. A study of the catecholamine metabolism permitted to detect certain aspects in the pathogenesis of different forms of extrapyramidal lesions in children.
作者对78例患有多病因神经系统锥体外系病变的儿童的儿茶酚胺代谢进行了研究。大多数病例为苍白球黑质综合征。在运动不能-强直型中检测到儿茶酚胺排泄量急剧下降，尤其是多巴胺和多巴。在扭转性肌肉变形性肌张力障碍中，多巴排泄量下降最为明显。在大多数病例中，在左旋多巴的病因治疗作用下，临床状态和儿茶酚胺代谢指标有所改善。对儿茶酚胺代谢的研究有助于发现儿童不同形式锥体外系病变发病机制中的某些方面。
