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[声带运动障碍和/或哮喘]

[Vocal cord dyskinesia and/or asthma].

作者信息

Braun J J, Delmas C, Charloux A, Schultz P, de Blay F

机构信息

Service d'ORL-CCF, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, 67098 Strasbourg cedex, France; Service de pneumologie et d'allergologie, pôle de pathologie thoracique, NHC, hôpitaux universitaires de Strasbourg, 67091 Strasbourg cedex, France.

Service de pneumologie et d'allergologie, pôle de pathologie thoracique, NHC, hôpitaux universitaires de Strasbourg, 67091 Strasbourg cedex, France.

出版信息

Rev Mal Respir. 2018 Jan;35(1):62-68. doi: 10.1016/j.rmr.2017.11.001. Epub 2018 Feb 1.

Abstract

INTRODUCTION

Vocal cord dyskinesia or vocal cord dysfunction (VCD) is characterized by intermittent abnormal adduction of the vocal cords leading to airflow limitation at the level of the larynx, in the absence of local organic disease. It may occur in isolation or in association with asthma. The pathophysiology is complex and poorly understood. Wheeze, stridor or apparent upper airway obstruction are the most common symptoms. It occurs in a wide age range, more commonly in women, and diagnosis is often delayed and leads to unnecessary treatments (intubation, tracheostomy and high dose steroids).

METHODS

A retrospective study of 15 cases of VCD (8 cases of isolated VCD and 7 cases of VCD with associated asthma) describing the main clinical features and the diagnosis strategy.

RESULTS

Apparent upper airway obstruction, with or without associated asthma, requires an ear nose and throat examination with laryngoscopy to confirm the paradoxical adduction of the vocal cords during an acute episode of dyspnoea or during a provocation test with triggers like exercise or exposure to irritants, and for the purpose of differential diagnosis.

CONCLUSIONS

VCD remains under-appreciated and misdiagnosed, often by mimicking asthma with which it can be associated. A delayed diagnosis by emergency specialists, pulmonologists and ear nose and throat surgeons leads to unnecessary treatments and morbidity before specific therapy can be given.

摘要

引言

声带运动障碍或声带功能障碍(VCD)的特征是声带间歇性异常内收,导致喉部气流受限,且不存在局部器质性疾病。它可能单独出现,也可能与哮喘相关。其病理生理学复杂,了解甚少。喘息、喘鸣或明显的上气道梗阻是最常见的症状。它发生于广泛的年龄范围,女性更为常见,诊断往往延迟并导致不必要的治疗(插管、气管切开术和高剂量类固醇)。

方法

对15例VCD患者(8例孤立性VCD和7例合并哮喘的VCD)进行回顾性研究,描述主要临床特征和诊断策略。

结果

明显的上气道梗阻,无论是否合并哮喘,在呼吸困难急性发作期间或在运动或接触刺激物等激发试验期间,都需要进行耳鼻喉检查及喉镜检查,以确认声带反常内收,并用于鉴别诊断。

结论

VCD常常未得到充分认识和误诊,常因与哮喘相似而被误诊。急诊专科医生、肺科医生和耳鼻喉外科医生的诊断延迟,会导致在给予特异性治疗之前出现不必要的治疗和发病率增加。

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