Normandie Université UNI Rouen, Service de Médecine Interne, CHU Charles Nicolle, 76000, Rouen, France.
Normandie Université UNI Rouen U1096, Service de Médecine Interne, CHU Charles Nicolle, 76000, Rouen, France.
Clin Rheumatol. 2018 Mar;37(3):849-853. doi: 10.1007/s10067-018-4007-4. Epub 2018 Feb 3.
Biotherapies appear as potential drugs for the treatment of inflammatory noninfectious uveitis. In this report, we show that tocilizumab, an anti-IL-6 agent, greatly improved two patients with birdshot chorioretinopathy refractory to conventional immunosuppressive drugs, interferon α2a, and anti-TNFα agents. After a follow-up of 22 months, patients exhibited an improvement of both visual acuity and macular edema. A corticosteroid-sparing effect was achieved in both cases.
生物疗法似乎是治疗炎症性非传染性葡萄膜炎的潜在药物。在本报告中，我们表明，托珠单抗（一种抗 IL-6 药物）极大地改善了两名对常规免疫抑制药物、干扰素 α2a 和抗 TNFα 药物难治的鸟枪弹样脉络膜视网膜病变患者的病情。随访 22 个月后，患者的视力和黄斑水肿均得到改善。两种情况下均实现了皮质类固醇的节省效应。
