Lee Sang Won, Yoo Jae Hyun, Kim Ko Woon, Kim Dongchan, Park HyunWook, Choi Jeewook, Teicher Martin H, Jeong Bumseok
Computational Affective Neuroscience and Development Laboratory, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea.
Clin Psychopharmacol Neurosci. 2018 Feb 28;16(1):46-56. doi: 10.9758/cpn.2018.16.1.46.
Reduced hippocampal volume and alterations in white matter tracts have been frequently reported in adults having the history of emotional maltreatment. We investigated whether these structural change occur in adolescents with previous verbal abuse (VA) experiences.
Hippocampal subfield volume and white matter structural connectivity measures were assessed in 31 first year male high school students with various degrees of exposure to parental and peer VA.
The high VA group showed significant volume reduction in the left cornu ammonis (CA) 1 and left subiculum compared to the low VA group (＜0.05). Volumes of left hippocampal subfields CA1 and subiculum were negatively correlated with previous VA experiences (＜0.05). Increased mean diffusivity (MD) of the splenium of the corpus callosum was related to high VA score across all subjects (＜0.05). There was an inverse relationship between volume of the CA1 and subiculum and MD of the splenium (＜0.05).
Exposure to parental and peer VA may affect development of the left hippocampal subfields and the splenium of corpus callosum. These structural alterations can be discernible during adolescence.
既往有情感虐待史的成年人中，海马体积减小和白质束改变屡有报道。我们调查了这些结构变化是否发生在有过言语虐待（VA）经历的青少年中。
对31名一年级男性高中生进行了海马亚区体积和白质结构连接性测量，这些学生曾遭受不同程度的来自父母和同伴的言语虐待。
与低言语虐待组相比，高言语虐待组左侧海马角（CA）1和左侧下托体积显著减小（＜0.05）。左侧海马亚区CA1和下托的体积与既往言语虐待经历呈负相关（＜0.05）。胼胝体压部平均扩散率（MD）增加与所有受试者的高言语虐待评分相关（＜0.05）。CA1和下托的体积与胼胝体压部的MD呈负相关（＜0.05）。
遭受来自父母和同伴的言语虐待可能会影响左侧海马亚区和胼胝体压部的发育。这些结构改变在青少年时期即可被察觉。
