Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Eur Psychiatry. 2019 Apr;57:70-77. doi: 10.1016/j.eurpsy.2019.01.016. Epub 2019 Feb 2.
The hippocampus is not a uniform structure, but rather consists of multiple, functionally specialized subfields. Few studies have explored hippocampal subfield volume difference in the same sample of major depressive disorder (MDD) and bipolar disorder (BD) cases. We aimed to investigate the difference of hippocampal subfield volume between patents with MDD and BD and healthy controls (HCs).
A total of 102 MDD and 55 BD patients and 135 HCs were recruited and underwent T1-weighted image. Hippocampal subfield volume was calculated by automated segmentation and volumetric procedures developed by Iglesias et al. and implemented in FreeSurfer. Volume differences between the groups were analyzed using the analysis of covariance and controlling for age, sex, and total intracranial cavity volume.
Patients with MDD had significantly reduced volumes in the bilateral cornu ammonis 1 (CA1), CA4, the granule cell layer (GCL), molecular layer (ML), whole hippocampus, the left CA2/3, and right presubiclum and subiculum. Patients with BD had significantly reduced volumes in the right CA1, GCL, and the whole hippocampus as compared to HCs. No significant volume differences were observed between the MDD and BD groups. Illness duration was negatively correlated with volumes of the left CA1, CA4, ML, presubiculum, subiculum, and the whole hippocampus in patients with BD.
We observed hippocampal subfield volume reductions in both MDD and BD, a finding which more prominent in MDD. The inverse correlation between BD illness duration and hippocampal subfield volume may evidence the neuroprogressive nature of BD.
海马体不是一个均匀的结构，而是由多个功能专业化的子区域组成。很少有研究在同一批重度抑郁症（MDD）和双相情感障碍（BD）患者样本中探讨海马体亚区体积差异。我们旨在探讨 MDD 和 BD 患者与健康对照（HCs）之间海马体亚区体积的差异。
共纳入 102 例 MDD 和 55 例 BD 患者和 135 例 HCs，并进行 T1 加权成像。海马体亚区体积由 Iglesias 等人开发并在 FreeSurfer 中实现的自动分割和容积程序计算。使用协方差分析和控制年龄、性别和总颅内腔体积对组间体积差异进行分析。
MDD 患者双侧角回 1（CA1）、CA4、颗粒细胞层（GCL）、分子层（ML）、整个海马体、左侧 CA2/3 和右侧前下托和下托体积明显减少。与 HCs 相比，BD 患者右侧 CA1、GCL 和整个海马体体积明显减少。MDD 和 BD 组之间未观察到明显的体积差异。BD 患者的病程与左侧 CA1、CA4、ML、前下托、下托和整个海马体的体积呈负相关。
我们观察到 MDD 和 BD 患者的海马体亚区体积减少，MDD 患者的减少更为明显。BD 疾病持续时间与海马体亚区体积呈负相关，这可能表明 BD 的神经进行性特征。
