Wang Li, Gao Rui, Liu Shu-Feng, Gao Chun-Ji
Department of Hematology,Chinese PLA General Hospital,Beijing 100853,China; Department of Hematology and Oncology,Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101, Shandong Province, China.
Department of Hematology and Oncology,Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101, Shandong Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Feb;26(1):302-306. doi: 10.7534/j.issn.1009-2137.2018.01.054.
Graft-versus-host disease (GVHD) and infection are the frequently encountered complications after hematopoietic stem cell transplantation (HSCT), which influence the outcome and limit the widespread application of HSCT. Intestinal microbiota plays an important role in maintaining intestinal immune balance. The diverse levels of intestinal microbiota associated with the incidences of GVHD, infection and the prognosis of HSCT, thus remodeling intestinal microbiota can alleviate GVHD and infection after HSCT. Herein, the recent research progress about the role and the involved mechanisms of intestinal microbiota in HSCT, and the novel manipulation strategies of intestinal microbiota are systematically reviewed.
移植物抗宿主病（GVHD）和感染是造血干细胞移植（HSCT）后常见的并发症，影响移植结局并限制了HSCT的广泛应用。肠道微生物群在维持肠道免疫平衡中起重要作用。肠道微生物群的不同水平与GVHD的发生率、感染及HSCT的预后相关，因此重塑肠道微生物群可减轻HSCT后的GVHD和感染。本文系统综述了肠道微生物群在HSCT中的作用、相关机制及新型调控策略的最新研究进展。
