Beika T, Tanaka N, Yamada J, Hizuta A, Onishi K, Akura Y, Hirose K, Orita K
Gan To Kagaku Ryoho. 1985 Feb;12(2):362-5.
After human recombinant beta-interferon (ReIFN-beta) was administered to 13 cancer patients intrathoracoperitoneally and by intravenous drip infusion every day or 3 times a week, the effect of peripheral lymphocytes on natural killer (NK) activity was studied. When ReIFN-beta was given every day or 3 times a week, the NK activity was notably enforced, and was maintained throughout the period of administration. NK activity was also enforced regardless of whether ReIFN-beta was given intravenously on intrathoracoperitoneally. By the administration of ReIFN-beta, pleural effusion and ascites in three patients were depleted, and in one patient, Douglas' cul-de-sac tumor disappeared. It was therefore suggested that ReIFN-beta was effective against the cavity of carcinomatosis.
对13例癌症患者每天或每周3次进行胸腔内和腹腔内注射以及静脉滴注人重组β-干扰素（ReIFN-β）后，研究了外周淋巴细胞对自然杀伤（NK）活性的影响。当每天或每周3次给予ReIFN-β时，NK活性显著增强，并在给药期间一直保持。无论ReIFN-β是静脉注射还是胸腔内和腹腔内注射，NK活性均增强。通过给予ReIFN-β，3例患者的胸腔积液和腹水减少，1例患者Douglas陷凹处的肿瘤消失。因此提示ReIFN-β对癌性体腔有效。
