Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan.
Department of Ophthalmology, University of the Ryukyus, Nishihara, Japan.
Eye (Lond). 2018 Jun;32(6):1062-1066. doi: 10.1038/s41433-017-0005-z. Epub 2018 Feb 5.
To report the clinical characteristics of eyes with an unmeasurable small size of foveal avascular zone (FAZ) in the optical coherence tomography angiographic (OCTA) images.
Two-hundred sixty-seven eyes of 255 patients (mean age 60.4 years) without retinal and choroidal disorders to cause any type of visual impairment were examined by optical coherence tomography angiography (OCTA; RTVue XR Avanti, Optovue, Fremont, CA). Cross-sectional images at the fovea (DRI-OCT, Topcon, Japan) and fundus autofluorescence (CX-1 MYD/NM, Canon, Japan) were also recorded from all eyes.
Four eyes (1.5%) of 3 patients (2 men, 1 woman; average age, 63.3 years) were found to have an unmeasurable small size of FAZ in the OCTA images. The best-corrected visual acuity was better than 20/20 in all eyes. Cross-sectional OCT images showed the presence of a foveal depression and the inner retinal layers in the foveal depression. These inner retinal layers were detected as a hyperreflective bands at the fovea. Fundus autofluorescence showed hypo-autofluorescence at the fovea as in normal eyes.
An unmeasurable small size of FAZ without visual impairment was detected in 1.5% of 267 normal eyes. These eyes may be classified as low-grade foveal hypoplasia.
报告光学相干断层扫描血管造影（OCTA）图像中无法测量的小范围黄斑中心凹无血管区（FAZ）的眼部临床特征。
对 255 例患者（平均年龄 60.4 岁）的 267 只眼进行了检查，这些患者均无视网膜和脉络膜疾病导致任何类型的视力损害。使用光学相干断层扫描血管造影（OCTA；RTVue XR Avanti，Optovue，弗里蒙特，加利福尼亚州）进行检查。所有眼睛均记录了黄斑中心凹的横截面图像（DRI-OCT，Topcon，日本）和眼底自发荧光（CX-1 MYD/NM，佳能，日本）。
在 3 名患者（2 名男性，1 名女性；平均年龄 63.3 岁）的 4 只眼中（1.5%）发现 OCTA 图像中存在无法测量的小范围 FAZ。所有眼睛的最佳矫正视力均优于 20/20。OCT 横截面图像显示存在黄斑凹陷和黄斑凹陷处的内层视网膜。这些内层视网膜在黄斑处表现为高反射带。眼底自发荧光显示黄斑处呈低自发荧光，与正常眼相似。
在 267 只正常眼中，有 1.5%（4 只眼）的 FAZ 无法测量，但视力不受影响。这些眼睛可能被归类为低度黄斑发育不良。
