Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510641, China.
Org Lett. 2018 Feb 16;20(4):1171-1174. doi: 10.1021/acs.orglett.8b00096. Epub 2018 Feb 5.
Herein, by employing dehydrogenation as a substrate-activating strategy, a new iridium-catalyzed direct α-functionalization of (hetero)aryl-fused cyclic secondary amines with indoles has been demonstrated, which proceeds with merits that include high step- and atom-efficiency, readily available feedstocks, a simple catalyst system, good functional group tolerance, and operational simplicity.
在此，通过采用脱氢作为底物激活策略，我们展示了一种新型的铱催化的（杂）芳基稠合环状仲胺与吲哚的直接α-官能化反应，该反应具有以下优点：高步骤和原子经济性、易得的原料、简单的催化剂体系、良好的官能团耐受性和操作简便性。
