Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology , Wushan Road-381, Guangzhou 510641 , People's Republic of China.
Org Lett. 2017 Jul 7;19(13):3390-3393. doi: 10.1021/acs.orglett.7b01349. Epub 2017 Jun 13.
Through cooperative actions of iridium catalyst and NaOTf additive we report a new direct access to nitrogen bi-heteroarenes via hydrogen-evolution cross-coupling of the β-site of indoles/pyrrole with the α-site of N-heteroarenes. The reaction proceeds in an atom- and redox-economic fashion together with the merits of an easily available catalyst system, broad substrate scope, excellent functional tolerance, and no need for external oxidants, offering a practical way to create π-conjugated systems.
通过铱催化剂和 NaOTf 添加剂的协同作用，我们报告了一种通过吲哚/吡咯的β位与 N-杂芳环的α位的氢消除交叉偶联，直接合成氮双杂芳环的新方法。该反应具有原子经济性和氧化还原经济性，催化剂体系易得，底物范围广，官能团容忍性好，无需外部氧化剂，为构建π共轭体系提供了一种实用的方法。
