[3H]尼群地平与正常血压大鼠、肾性高血压大鼠、脱氧皮质酮/氯化钠诱导高血压大鼠及自发性高血压大鼠心肌和脑膜的结合。

Binding of [3H]nitrendipine to cardiac and cerebral membranes from normotensive and renal, deoxycorticosterone/NaCl and spontaneously hypertensive rats.

作者信息

Ishii K, Kano T, Ando J, Yoshida H

出版信息

Eur J Pharmacol. 1986 Apr 16;123(2):271-8. doi: 10.1016/0014-2999(86)90668-0.

Abstract

The properties of [3H]nitrendipine binding to cardiac and cerebral membranes from normotensive Wistar-Kyoto (WKY) and renal (RHR), deoxycorticosterone/NaCl (DOCA-HR) and spontaneously hypertensive (SHR) rats were investigated. The maximal numbers of binding sites (Bmax) in the striatum, thalamus and hippocampus for SHR increased by 21.4-40.0, 28.1-40.4 and 21.4-34.1% of the numbers in WKY, but the apparent dissociation constants (KD) in the cerebral membranes differed very little between WKY and SHR. In the cardiac membranes, KD and Bmax values differed very little between WKY and SHR. In the RHR and DOCA-HR, the Bmax values in the striatum, thalamus and hippocampus were similar to those of WKY. These findings suggest that the increase in Bmax of [3H]nitrendipine in the striatum, thalamus and hippocampus of SHR may play a part in the development and maintenance of high blood pressure in SHR.

摘要

研究了[3H]尼群地平与正常血压的Wistar-Kyoto（WKY）大鼠、肾性高血压（RHR）大鼠、脱氧皮质酮/氯化钠（DOCA-HR）大鼠和自发性高血压（SHR）大鼠的心脏和脑膜的结合特性。SHR纹状体、丘脑和海马体中结合位点的最大数量（Bmax）比WKY大鼠相应部位增加了21.4%-40.0%、28.1%-40.4%和21.4%-34.1%，但WKY和SHR大鼠脑膜中的表观解离常数（KD）差异很小。在心脏膜中，WKY和SHR的KD和Bmax值差异也很小。在RHR和DOCA-HR大鼠中，纹状体、丘脑和海马体的Bmax值与WKY大鼠相似。这些发现表明，SHR纹状体、丘脑和海马体中[3H]尼群地平Bmax的增加可能在SHR高血压的发生和维持中起作用。