Goa K L, Sorkin E M
Drugs. 1987 Feb;33(2):123-55. doi: 10.2165/00003495-198733020-00003.
Nitrendipine is a calcium entry blocker shown to inhibit the movement of calcium through the 'slow channel' of cardiac and vascular smooth muscle, thus inducing peripheral vasodilation with consequent reductions in elevated blood pressure. As evidenced by clinical trials, nitrendipine promptly lowers blood pressure in patients with mild to moderate hypertension, and sustains this effect during long term administration. Combining nitrendipine with other antihypertensive agents such as diuretics or beta-blockers often results in successful treatment in patients unresponsive to nitrendipine monotherapy. Headache, oedema, flushing and palpitations commonly occurring during treatment with nitrendipine are generally mild, usually subsiding with continued therapy. Thus, although additional long term studies are required to properly assess the relative merits of the drug compared with other antihypertensives, by providing the clinician with an effective and safe alternative to traditional therapies, nitrendipine represents a step forward in the treatment of mild to moderate hypertension.
尼群地平是一种钙通道阻滞剂，可抑制钙通过心脏和血管平滑肌的“慢通道”移动，从而引起外周血管舒张，进而降低升高的血压。临床试验证明，尼群地平能迅速降低轻度至中度高血压患者的血压，并在长期给药期间维持这种效果。将尼群地平与其他抗高血压药物（如利尿剂或β受体阻滞剂）联合使用，通常能成功治疗对尼群地平单一疗法无反应的患者。尼群地平治疗期间常见的头痛、水肿、潮红和心悸一般较轻，通常会随着持续治疗而消退。因此，尽管需要更多长期研究来正确评估该药物与其他抗高血压药物相比的相对优点，但通过为临床医生提供一种有效且安全的传统疗法替代方案，尼群地平在轻度至中度高血压的治疗方面向前迈进了一步。
