Oranje A P, van Joost T, van Reede E C, Vuzevski V D, Dzoljic-Danilovic G, ten Kate F J, Stolz E
Dermatologica. 1986;172(4):191-5.
The pathomechanisms of infantile seborrheic dermatitis (ISD) are unknown. An allergic reaction to candidal antigens is one of the hypotheses. The skin of 6 patients suffering from ISD was studied by immunostaining techniques. The lymphocytic infiltrate was composed of Leu4-reactive T cells in which Leu3a-reactive (helper/inducer) cells predominated. Direct immunofluorescence studies revealed no significant deposits of immunoglobulins or complement factors. No candidal antigens could be demonstrated, either in epidermis or in dermis, although candida species were cultured from different sites in 4 of the 6 patients.
婴儿脂溢性皮炎（ISD）的发病机制尚不清楚。对念珠菌抗原的过敏反应是其中一种假说。采用免疫染色技术对6例ISD患者的皮肤进行了研究。淋巴细胞浸润由Leu4反应性T细胞组成，其中以Leu3a反应性（辅助/诱导）细胞为主。直接免疫荧光研究未发现免疫球蛋白或补体因子的显著沉积。尽管在6例患者中的4例不同部位培养出了念珠菌，但在表皮或真皮中均未检测到念珠菌抗原。
