Toronto General Hospital Research Institute, University Health Network, 101 College Street, PMCRT - MaRS Centre, Toronto, Ontario M5G 1L7, Canada.
Department of Cell & Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada.
FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny026.
The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in understanding within-host diversity and antimicrobial resistance in P. aeruginosa populations from the lower airways of individuals with the fatal genetic disease cystic fibrosis and the potential impacts that this diversity may have on detecting and interpreting antimicrobial susceptibility within these populations.
细菌病原体在人类宿主中的进化和多样化代表了诊断和治疗危及生命的感染的潜在障碍。在感染患有慢性肺部疾病的个体气道的铜绿假单胞菌菌株中，宿主适应性具有巨大的遗传和表型多样性，并且事实证明这些菌株极难根除。在这篇 MiniReview 中，我们研究了在患有致命遗传疾病囊性纤维化的个体的下呼吸道中，对铜绿假单胞菌种群的宿主内多样性和抗微生物药物耐药性的最新理解进展，以及这种多样性可能对这些种群中的抗微生物药物敏感性检测和解释产生的潜在影响。
