一个自身反应性小鼠甲状腺球蛋白特异性T细胞克隆的辅助和抑制活性

Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.

作者信息

Champion B R, Hutchings P, Davies S, Marshall-Clarke S, Cooke A, Roitt I M

出版信息

Immunology. 1986 May;58(1):51-6.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1452646/

Abstract

An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following specific triggering with antigen. Furthermore, antigen-stimulated clone cells were capable of providing bystander help in SRBC-specific antibody responses. Surprisingly, MTg9B3 cells had a profound suppressive effect on thyroglobulin autoantibody responses in vitro.

摘要

已对一种针对小鼠甲状腺球蛋白的自身反应性T细胞克隆MTg9B3进行了特性鉴定。该克隆具有与自身反应性T辅助细胞相符的特性。它受I-A限制，表面表型为Thy 1+、L3T4+、Ly2-，在用抗原进行特异性触发后会产生多种非特异性淋巴因子活性。此外，抗原刺激的克隆细胞能够在针对绵羊红细胞（SRBC）的特异性抗体反应中提供旁观者辅助。令人惊讶的是，MTg9B3细胞在体外对甲状腺球蛋白自身抗体反应具有显著的抑制作用。

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本文引用的文献

1

Syngeneic thyroglobulin is immunogenic in good responder mice.同基因甲状腺球蛋白在反应良好的小鼠中具有免疫原性。

Eur J Immunol. 1981 Feb;11(2):146-51. doi: 10.1002/eji.1830110216.

2

Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. II. T and B cell involvement in primary responses.小鼠淋巴细胞在甲状腺上皮细胞单层上的同基因致敏作用。II. T细胞和B细胞在初次反应中的参与情况。

Eur J Immunol. 1982 May;12(5):416-21. doi: 10.1002/eji.1830120511.

3

H-2-unrestricted polyclonal maturation without replication of small B cells induced by antigen-activated T cell help factors.由抗原激活的T细胞辅助因子诱导的小B细胞的H-2非限制性多克隆成熟且无复制。

Eur J Immunol. 1980 Sep;10(9):679-85. doi: 10.1002/eji.1830100905.

4

T-cell regulation in autoimmune thyroiditis.自身免疫性甲状腺炎中的T细胞调节

Immunol Rev. 1981;55:299-314. doi: 10.1111/j.1600-065x.1981.tb00346.x.

5

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.在不同功能检测中具有活性的两类不同小鼠B细胞生长因子的证据。

J Exp Med. 1983 Sep 1;158(3):822-35. doi: 10.1084/jem.158.3.822.

6

A requirement for nonspecific T cell factors in antibody responses to "T cell independent" antigens.对“T细胞非依赖性”抗原产生抗体反应时非特异性T细胞因子的需求。

J Immunol. 1983 Feb;130(2):781-4.

7

Regulation of B-cell growth and differentiation by soluble factors.可溶性因子对B细胞生长和分化的调节

Annu Rev Immunol. 1983;1:307-33. doi: 10.1146/annurev.iy.01.040183.001515.

8

T cell competence to heterologous and homologous thyroglobulins during the induction of experimental autoimmune thyroiditis.实验性自身免疫性甲状腺炎诱导过程中T细胞对异源和同源甲状腺球蛋白的反应能力。

Eur J Immunol. 1984 Oct;14(10):887-93. doi: 10.1002/eji.1830141005.

9

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis.克隆化辅助性T细胞在存在特异性抗原的情况下可杀伤B淋巴瘤细胞：细胞溶解中的Ia限制以及同源与非同源相互作用

Eur J Immunol. 1984 Oct;14(10):878-86. doi: 10.1002/eji.1830141004.

10

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