Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY, United States.
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY, United States.
Front Neuroendocrinol. 2018 Apr;49:86-90. doi: 10.1016/j.yfrne.2018.01.002. Epub 2018 Feb 2.
Impacts of steroid stress hormones on the brain have provided multiple opportunities for linking specific molecular phenomena to behavioral state. The negative impacts of stress on female reproductive biological processes have been documented thoroughly at the endocrine and behavioral levels. More recently, a '3-hit' theory of autism has identified early stress as one of the hits. The multiple biochemical effects of endotoxin (lipopolysaccharide, LPS) indicated that it would serve as a powerful maternal immune activator. The prenatal exposure to LPS coupled with the other two 'hits'- an autism-related mutation and the Y chromosome - - heightened certain autism-like signs in mouse behavior.
类固醇应激激素对大脑的影响为将特定的分子现象与行为状态联系起来提供了多种机会。压力对女性生殖生物过程的负面影响在内分泌和行为水平上得到了充分的记录。最近，自闭症的“三击”理论确定早期压力是其中之一。内毒素（脂多糖，LPS）的多种生化作用表明，它将作为一种强大的母体免疫激活剂。产前接触 LPS 加上另外两个“打击”-与自闭症相关的突变和 Y 染色体- -在老鼠行为中增强了某些类似自闭症的迹象。
