Gurpide E, Markiewicz L, Schatz F, Hirata F
J Clin Endocrinol Metab. 1986 Jul;63(1):162-6. doi: 10.1210/jcem-63-1-162.
Lipocortin was found to be secreted by human endometrium incubated for 1-2 days under organ culture conditions. Levels of lipocortin in the culture medium, measured by RIA, were increased by dexamethasone (10(-8)-10(-6) M) and decreased by progesterone (10(-8)-10(-6) M). Both steroids, however, decreased prostaglandin F2 alpha (PGF2 alpha) output, also estimated by RIA. These results suggest that lipocortin does not mediate the inhibition of PGF2 alpha production evoked by progesterone. Dexamethasone may inhibit PGF2 alpha production by mechanisms involved in the inhibition by progesterone in addition to those mediated by an elevation in the levels of lipocortin, a phospholipase inhibitor.
研究发现，在器官培养条件下培养1 - 2天的人子宫内膜可分泌脂皮质素。通过放射免疫分析法（RIA）测定，培养基中脂皮质素的水平可被地塞米松（10⁻⁸ - 10⁻⁶M）升高，而被孕酮（10⁻⁸ - 10⁻⁶M）降低。然而，这两种类固醇激素均会降低同样通过放射免疫分析法估算的前列腺素F2α（PGF2α）的分泌量。这些结果表明，脂皮质素并不介导孕酮所引起的PGF2α生成的抑制作用。除了通过升高作为磷脂酶抑制剂的脂皮质素水平所介导的机制外，地塞米松可能还通过与孕酮抑制作用相关的机制来抑制PGF2α的生成。
