硫酸软骨素 CC 和 DD 四糖的合成及其与 2H6 和 LY111 的相互作用。
Synthesis of chondroitin sulfate CC and DD tetrasaccharides and interactions with 2H6 and LY111.
机构信息
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyamacho-Minami 4-101, Tottori 680-8552, Japan.
Department of Regional Environment, Faculty of Regional Sciences, Tottori University, Koyamacho-Minami 4-101, Tottori 680-8551, Japan.
出版信息
Bioorg Med Chem. 2018 Mar 1;26(5):1016-1025. doi: 10.1016/j.bmc.2018.01.011. Epub 2018 Feb 3.
We synthesized the biotinylated chondroitin sulfate tetrasaccharides CS-CC [-3)βGalNAc6S(1-4)βGlcA(1-] and CS-DD [-3)βGalNAc6S(1-4)βGlcA2S(1-] which possess sulfate groups at O-6 of GalNAc and an additional sulfate group at O-2 of GlcA, respectively. We also analyzed interactions among CS-CC and CS-DD and the antibodies 2H6 and LY111, both of which are known to bind with CS-A, while CS-DD was shown for the first time to bind with both antibodies.
我们合成了带有生物素标记的硫酸软骨素四糖 CS-CC[-3)βGalNAc6S(1-4)βGlcA(1-]和 CS-DD[-3)βGalNAc6S(1-4)βGlcA2S(1-]，它们分别在 GalNAc 的 O-6 位和 GlcA 的 O-2 位带有硫酸基团。我们还分析了 CS-CC 和 CS-DD 与 2H6 和 LY111 抗体之间的相互作用，这两种抗体都已知与 CS-A 结合，而 CS-DD 则首次被证明与这两种抗体都结合。
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