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迷走感觉神经元上的Mrgprs会导致支气管收缩和气道高反应性。

Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

作者信息

Han Liang, Limjunyawong Nathachit, Ru Fei, Li Zhe, Hall Olivia J, Steele Haley, Zhu Yuyan, Wilson Julie, Mitzner Wayne, Kollarik Marian, Undem Bradley J, Canning Brendan J, Dong Xinzhong

机构信息

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

出版信息

Nat Neurosci. 2018 Mar;21(3):324-328. doi: 10.1038/s41593-018-0074-8. Epub 2018 Feb 5.

DOI:10.1038/s41593-018-0074-8
PMID:29403029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5857222/
Abstract

Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

摘要

哮喘伴有肺部炎症、支气管收缩和气道高反应性，是一项重大的公共卫生负担。我们在此报告，Mas相关G蛋白偶联受体（Mrgprs）在支配气道的一部分迷走感觉神经元中表达，并介导胆碱能性支气管收缩和气道高反应性。这些发现为哮喘发病机制的神经机制提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/5783f25ce50a/nihms930942f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/443026604042/nihms930942f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/fb5ace02f171/nihms930942f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/5783f25ce50a/nihms930942f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/443026604042/nihms930942f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/fb5ace02f171/nihms930942f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7a/5857222/5783f25ce50a/nihms930942f3.jpg

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