London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, England.
International Health Policy Programme, Ministry of Public Health, Nonthaburi 110000, Thailand.
Bull World Health Organ. 2018 Feb 1;96(2):101-109. doi: 10.2471/BLT.17.199679. Epub 2018 Jan 2.
To analyse how antibiotics are imported, manufactured, distributed and regulated in Thailand.
We gathered information, on antibiotic distribution in Thailand, in in-depth interviews - with 43 key informants from farms, health facilities, pharmaceutical and animal feed industries, private pharmacies and regulators- and in database and literature searches.
In 2016-2017, licensed antibiotic distribution in Thailand involves over 700 importers and about 24 000 distributors - e.g. retail pharmacies and wholesalers. Thailand imports antibiotics and active pharmaceutical ingredients. There is no system for monitoring the distribution of active ingredients, some of which are used directly on farms, without being processed. Most antibiotics can be bought from pharmacies, for home or farm use, without a prescription. Although the 1987 Drug Act classified most antibiotics as "dangerous drugs", it only classified a few of them as prescription-only medicines and placed no restrictions on the quantities of antibiotics that could be sold to any individual. Pharmacists working in pharmacies are covered by some of the Act's regulations, but the quality of their dispensing and prescribing appears to be largely reliant on their competences.
In Thailand, most antibiotics are easily and widely available from retail pharmacies, without a prescription. If the inappropriate use of active pharmaceutical ingredients and antibiotics is to be reduced, we need to reclassify and restrict access to certain antibiotics and to develop systems to audit the dispensing of antibiotics in the retail sector and track the movements of active ingredients.
分析泰国抗生素的进口、生产、分销和监管情况。
我们通过深入访谈(对来自农场、卫生机构、制药和动物饲料行业、私营药店和监管机构的 43 名关键知情者进行访谈)以及数据库和文献搜索,收集了泰国抗生素分销方面的信息。
在 2016-2017 年,泰国获得许可的抗生素分销涉及 700 多家进口商和约 24000 家分销商,如零售药店和批发商。泰国进口抗生素和原料药。没有监测原料药分销的系统,其中一些原料药在未经加工的情况下直接用于农场。大多数抗生素可以从药店购买,用于家庭或农场用途,无需处方。尽管 1987 年《药品法》将大多数抗生素归类为“危险药物”,但它只将其中一些归类为凭处方购买的药品,对可向任何个人出售的抗生素数量没有限制。在药店工作的药剂师受该法案某些规定的约束,但他们的配药和处方质量似乎在很大程度上取决于他们的能力。
在泰国,大多数抗生素无需处方即可从零售药店轻松广泛获得。如果要减少原料药和抗生素的不当使用,我们需要重新分类并限制某些抗生素的使用,并开发系统来审计零售部门的抗生素配药情况,并跟踪原料药的流动情况。