Agrawal Sonu, Verma Nishant, Perumalla Sowjanya, Mirdha Bijay Ranjan
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
J Lab Physicians. 2018 Jan-Mar;10(1):31-33. doi: 10.4103/JLP.JLP_91_17.
Globally, amoebic liver abscess, a common extraintestinal complication of intestinal amoebiasis. Diagnosis of hepatic amoebiasis is based on the detection of anti- immunoglobulin G (IgG) antibody using enzyme-linked immunosorbent assay (ELISA), because of its technique's relatively higher sensitivity and specificity (90%).
The aim of the present study was to determine the seroprevalence of hepatic amoebiasis in a referral tertiary care hospital in North India.
The blood samples were tested specifically for anti- IgG antibody using commercially available ELISA kit (RIDASCREEN IgG [K1721] kit).
A total of 879 patients ( = 879) were evaluated, of which 78.49% (690/879) were positive for anti- IgG antibody. The seroprevalence rates showed a declining trend from 2010 to 2015 with rates falling from 91.4% to 66.7%. He present a study showed the decreasing trend of seroprevalence of hepatic amoebiasis from 2010 to 2015.
This decrease may be attributed to several factors such as increase in awareness, improved hygienic practices, use of safe drinking water, better socioeconomic condition, and perhaps early treatment sought for intestinal amoebiasis.
在全球范围内，阿米巴肝脓肿是肠道阿米巴病常见的肠外并发症。肝阿米巴病的诊断基于使用酶联免疫吸附测定（ELISA）检测抗免疫球蛋白G（IgG）抗体，因为该技术具有相对较高的敏感性和特异性（90%）。
本研究的目的是确定印度北部一家三级转诊医院中肝阿米巴病的血清流行率。
使用市售ELISA试剂盒（RIDASCREEN IgG [K1721]试剂盒）对血样进行抗IgG抗体的特异性检测。
共评估了879例患者（n = 879），其中78.49%（690/879）抗IgG抗体呈阳性。血清流行率从2010年到2015年呈下降趋势，比率从91.4%降至66.7%。本研究显示2010年至2015年肝阿米巴病血清流行率呈下降趋势。
这种下降可能归因于多种因素，如意识提高、卫生习惯改善、使用安全饮用水、更好的社会经济状况，以及可能对肠道阿米巴病寻求早期治疗。
