Zhu Hanyu, Han Qiuxia, Zhang Dong, Wang Yong, Gao Jing, Yang Xiaoli, Geng Wenjia, Chen Xiangmei
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, China.
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Int J Nephrol Renovasc Dis. 2018 Jan 18;11:33-40. doi: 10.2147/IJNRD.S149029. eCollection 2018.
Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN.
A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests.
Among the 231 MN cases, the ratio of male to female was 1.47 and the mean age was 47.43±14.32 years. Altogether, 163 (70.6%) cases were positive for NS. Their serum antiPLA2R, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, D2, IgA, and IgE were increased, but IgG was decreased. The majority of the patients were middle aged and old aged. In addition, the pathological stage was significantly correlated with gender (=0.038), creatinine, (=0.021) and IgE (=0.003). A total of 74.9% MN patients were found to be positive for anti-PLA2R antibodies, and they were more likely to have abnormal serum indices.
The major clinicopathological characteristics of MN patients are summarized in this study. Male and elder MN cases are likely to have rapid disease progression. Advanced pathological stages and being positive for anti-PLA2R antibodies may be potential indicators for disease activity of MN.
膜性肾病（MN）是一种独特的肾小球疾病，被认为是成人肾病综合征（NS）的主要病因。证据表明，MN患者的临床病理特征各不相同。本研究旨在总结和分析MN患者的临床病理特征。
本研究共纳入231例MN患者。根据患者的年龄、性别、病理分期和抗磷脂酶A2受体（抗PLA2R）抗体检测结果，收集并分析其临床和病理特征。
在231例MN患者中，男女比例为1.47，平均年龄为47.43±14.32岁。共有163例（70.6%）患者NS阳性。他们的血清抗PLA2R、体重指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、D2、IgA和IgE升高，但IgG降低。大多数患者为中老年。此外，病理分期与性别（=0.038）、肌酐（=0.021）和IgE（=0.003）显著相关。共发现74.9%的MN患者抗PLA2R抗体阳性，且他们更易出现血清指标异常。
本研究总结了MN患者的主要临床病理特征。男性和老年MN患者疾病进展可能较快。病理分期较晚和抗PLA2R抗体阳性可能是MN疾病活动的潜在指标。
