Department of Nephrology, The First Affiliated Hospital of Nan Chang University, Nanchang, China.
Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang City, China.
Ren Fail. 2022 Dec;44(1):987-993. doi: 10.1080/0886022X.2022.2083517.
Primary glomerular disease was the leading cause of chronic kidney disease (CKD) in China; however, changes in the economy and environment introduce variations in the spectrum of kidney diseases. This study aimed to analyze renal biopsy data to inform disease prevention and public health interventions. In this retrospective cohort study, data from 2,803 consecutive renal biopsies conducted at our center between January 2010 and December 2018 were analyzed. The sample was disaggregated by age and the date of biopsy to facilitate analysis. Primary glomerulonephritis (PGN) is the most frequent (81.84%) finding, followed by secondary glomerulonephritis (SGN; 15.38%), tubulointerstitial nephritis (15.38%), and others (1.57%). IgA nephropathy (IgAN), idiopathic membranous nephropathy (iMN), and minimal change disease were the primary causes of PGN. Among PGN cases, the incidence of iMN arose, especially among those aged ≥ 60 years old, during the observation period. Contrary to the case of iMN, the proportion of IgAN in PGN trended downward, continuously, and at length. Moreover, IgAN mainly affected those aged 25-44 years old and less so those aged ≥ 60 years old. Lupus nephritis, Henoch-Schönlein purpura nephritis, and diabetic nephropathy (DN) were key causes of SGN. A ratio reversal between infectious disease and chronic disease dramatically changed SGN patterns. In the past year, the incidence of hepatitis B-related nephritis has constantly declined; however, the proportion of DN among SGN had steadily increased. The incidence of iMN significantly increased during these years. Among SGN cases, the proportion of DN has increased.
原发性肾小球疾病是中国慢性肾脏病（CKD）的主要病因；然而，经济和环境的变化导致了肾脏疾病谱的变化。本研究旨在分析肾活检资料，为疾病预防和公共卫生干预提供信息。在这项回顾性队列研究中，我们分析了 2010 年 1 月至 2018 年 12 月在我院进行的 2803 例连续肾活检的资料。按年龄和活检日期对样本进行细分，便于分析。原发性肾小球肾炎（PGN）最常见（81.84%），其次是继发性肾小球肾炎（SGN；15.38%）、肾小管间质性肾炎（15.38%）和其他疾病（1.57%）。IgA 肾病（IgAN）、特发性膜性肾病（iMN）和微小病变性肾病是 PGN 的主要原因。在 PGN 病例中，iMN 的发病率在观察期间上升，尤其是在≥60 岁的人群中。与 iMN 相反，IgAN 在 PGN 中的比例持续下降。此外，IgAN 主要影响 25-44 岁的人群，较少影响≥60 岁的人群。狼疮性肾炎、过敏性紫癜性肾炎和糖尿病肾病（DN）是 SGN 的主要病因。传染病和慢性病之间的比例逆转导致 SGN 模式发生显著变化。在过去一年中，乙型肝炎相关性肾炎的发病率持续下降；然而，DN 在 SGN 中的比例稳步上升。近年来，iMN 的发病率显著增加。在 SGN 病例中，DN 的比例增加。
