Burnett Marianne E, Adebesin Bokola, Funk Alexander M, Kovacs Zoltan, Sherry A Dean, Ekanger Levi A, Allen Matthew J, Green Kayla N, Ratnakar S James
Department of Chemistry and Biochemistry, Texas Christian University, Fort Worth, Texas 76129.
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas 75390.
Eur J Inorg Chem. 2017 Nov 24;2017(43):5001-5005. doi: 10.1002/ejic.201701070. Epub 2017 Nov 21.
The Eu redox couple provides a convenient design platform for responsive O sensors for magnetic resonance imaging (MRI). Specifically the Eu ion provides contrast enhancement under hypoxic conditions in tissues, whereas, under normoxia, the Eu ion can produce contrast from chemical exchange saturation transfer in MRI. The oxidative stability of the Eu redox couple for a series of tetraaza macrocyclic complexes was investigated in this work using cyclic voltammetry. A series of Eu-containing cyclen-based macrocyclic complexes revealed positive shifts in the Eu redox potentials with each replacement of a carboxylate coordinating arm of the ligand scaffold with glycinamide pendant arms. The data obtained reveal that the complex containing four glycinamide coordinating pendant arms has the highest oxidative stability of the series investigated.
铕氧化还原对为用于磁共振成像（MRI）的响应型氧传感器提供了一个便利的设计平台。具体而言，铕离子在组织缺氧条件下可增强对比度，而在正常氧水平下，铕离子可通过磁共振成像中的化学交换饱和转移产生对比度。本工作使用循环伏安法研究了一系列四氮杂大环配合物的铕氧化还原对的氧化稳定性。一系列含铕的基于环烯的大环配合物显示，随着配体支架的羧酸根配位臂每次被甘氨酰胺侧链取代，铕氧化还原电位发生正向偏移。所获得的数据表明，在所研究的系列中，含有四个甘氨酰胺配位侧链的配合物具有最高的氧化稳定性。
