Basal Lina A, Allen Matthew J
Department of Chemistry, Wayne State University, Detroit, MI, United States.
Front Chem. 2018 Mar 19;6:65. doi: 10.3389/fchem.2018.00065. eCollection 2018.
Considerable research effort has focused on the use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is Eu-containing complexes because the Eu redox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of Eu requires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete Eu-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous Eu-containing complexes.
大量的研究工作集中在使用响应性成像探针上，这些探针在与氧气反应时会改变成像特性，因为缺氧与疾病的诊断、治疗和监测相关。一类有前景的用于氧响应成像的化合物是含铕配合物，因为铕氧化还原对能够实现包括磁共振和光声成像在内的多种模态成像。使用铕时需要小心处理，以避免在合成和表征过程中意外氧化。本综述描述了基于离散含铕配合物的成像剂领域的最新进展，特别关注含水含铕配合物的合成、表征和处理。
