Lenora Chamika U, Carniato Fabio, Shen Yimin, Latif Zahid, Haacke E Mark, Martin Philip D, Botta Mauro, Allen Matthew J
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Dipartimento di Scienze e Innovazione Tecnologica, Universitâ del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121, Alessandria, Italy.
Chemistry. 2017 Nov 2;23(61):15404-15414. doi: 10.1002/chem.201702158. Epub 2017 Aug 22.
Eu -containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of Eu -containing cryptates and their adducts with β-cyclodextrins, poly-β-cyclodextrins, and human serum albumin. Solid- and solution-phase characterization of Eu -containing complexes is presented that demonstrates the presence of inner-sphere molecules of water. Additionally, relaxivity, water-exchange rate, rotational correlation time, and electronic relaxation times were determined using variable-temperature O NMR, nuclear magnetic relaxation dispersion, and electron paramagnetic resonance spectroscopic techniques. These results are expected to be instrumental in the design of future Eu -based contrast agents.
研究了含铕配合物作为磁共振成像造影剂的相关性质。针对一系列含铕穴状化合物及其与β-环糊精、聚-β-环糊精和人血清白蛋白的加合物，研究了分子参数和场强对弛豫率的影响。给出了含铕配合物的固相和溶液相表征，证明了内球水分子的存在。此外，使用变温¹⁷O核磁共振、核磁共振弛豫色散和电子顺磁共振光谱技术测定了弛豫率、水交换率、旋转相关时间和电子弛豫时间。这些结果有望为未来基于铕的造影剂的设计提供帮助。
