Suchkov Dmitrii, Sharipzyanova Lyaila, Minlebaev Marat
Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
INMED-INSERM U901, Aix-Marseille Université, Marseille, France.
Front Cell Neurosci. 2018 Jan 19;12:5. doi: 10.3389/fncel.2018.00005. eCollection 2018.
During development, activity in the somatosensory cortex is characterized by intermittent oscillatory bursts at gamma (early gamma-oscillations, EGOs) and alpha-beta (spindle-bursts, SBs) frequencies. Here, we explored the topography of EGOs and SBs in the neighbor barrels of the whisker-related barrel cortex of neonatal rats (P4-7) during responses evoked by simultaneous activation of multiple whiskers as it occurs during natural conditions. We found that brief simultaneous deflection of all whiskers evoked complex neuronal responses comprised of EGOs and SBs. In contrast to EGOs, that specifically synchronized neuronal activity in each individual barrel, SBs efficiently synchronized activity between neighboring barrels. After plucking a single whisker, synchronous stimulation of spared whiskers evoked EGO-lacking responses in the whisker-deprived barrel, even though the remaining neuronal activity was synchronized by SBs in neighboring barrels. Thus, EGOs specifically support topographic synchronization of neuronal activity within barrels, whereas SBs support horizontal synchronization between neighboring barrels during stimulation of multiple whiskers. We suggest that these two co-existing activity patterns coordinate activity-dependent formation of topographic maps and support the emergence of integrative functions in the primary somatosensory cortex during the critical period of somatosensory maps development.
在发育过程中，体感皮层的活动特征是在伽马频率（早期伽马振荡，EGOs）和阿尔法-贝塔频率（纺锤体爆发，SBs）出现间歇性振荡爆发。在此，我们探究了新生大鼠（P4-7）与胡须相关的桶状皮层相邻桶中EGOs和SBs的拓扑结构，这些桶状皮层在自然条件下由多根胡须同时激活所诱发的反应期间。我们发现，所有胡须的短暂同时偏转诱发了由EGOs和SBs组成的复杂神经元反应。与在每个单独桶中特异性同步神经元活动的EGOs不同，SBs有效地同步了相邻桶之间的活动。拔掉一根胡须后，对剩余胡须的同步刺激在胡须缺失的桶中诱发了缺乏EGO的反应，尽管剩余的神经元活动由相邻桶中的SBs同步。因此，EGOs特异性地支持桶内神经元活动的拓扑同步，而SBs在多根胡须刺激期间支持相邻桶之间的水平同步。我们认为，这两种共存的活动模式协调了与活动相关的拓扑图形成，并在体感图发育的关键时期支持初级体感皮层中整合功能的出现。
