Corson S L, Batzer F, Eisenberg E, English M E, White S M, Laberge Y, Go K J
J Reprod Med. 1986 Apr;31(4):219-23.
Gamete intrafallopian transfer (GIFT) was performed in 19 cycles on 15 couples whose infertility had proven resistant to other treatments. Indications included infertility associated with immunologic factors, seminal deficiencies, endometriosis and infertility without a diagnosed etiology. Any history or finding of tubal disease served as an exclusion. Infertility was primary in ten couples and secondary in five, three of whom had conceived previously with a semen donor. Stimulation protocols included clomiphene citrate (CC) and human menopausal gonadotropins, CC alone and gonadotropins alone. Males were screened with the hamster egg sperm penetration assay. Four conceptions were recorded, and three are ongoing. Advantages of this procedure include acceptance by the major orthodox religions, avoidance of extracorporeal incubation and physiologic entry of the embryo into the uterine cavity. Disadvantages include the inability to determine if fertilization has occurred in the absence of pregnancy, the theoretical risk of increased ectopic gestation and tubal infection, and perhaps an increase in multiple gestations.
对15对夫妇进行了19个周期的配子输卵管内移植（GIFT），这些夫妇的不孕症经证实对其他治疗有抵抗性。适应症包括与免疫因素、精液缺陷、子宫内膜异位症相关的不孕症以及病因未明的不孕症。任何输卵管疾病的病史或检查结果均作为排除标准。10对夫妇为原发性不孕，5对为继发性不孕，其中3对曾通过精液捐赠者受孕。刺激方案包括枸橼酸氯米芬（CC）和人绝经期促性腺激素、单独使用CC以及单独使用促性腺激素。男性通过仓鼠卵精子穿透试验进行筛查。记录到4例受孕，3例仍在进行中。该程序的优点包括被主要正统宗教所接受、避免体外培养以及胚胎生理性进入子宫腔。缺点包括在未怀孕的情况下无法确定是否发生受精、理论上宫外孕和输卵管感染增加的风险，以及可能多胎妊娠增加。
