Kirkland Joseph J, Schuster Stephanie A, Johnson William L, Boyes Barry E
Advanced Materials Technology, Inc., 3521 Silverside Road, Suite 1-K, Quillen Building, Wilmington, DE 19810, USA.
Complex Carbohydrate Research Center, 315 Riverbend Road, Athens, GA 30602, USA.
J Pharm Anal. 2013 Oct;3(5):303-312. doi: 10.1016/j.jpha.2013.02.005. Epub 2013 Feb 27.
The advent of superficially porous particles (SPPs) for packed HPLC columns has changed the way that many practitioners have approached the problem of developing needed separations. The very high efficiency of such columns, combined with convenient operating conditions, modest back pressures and the ability to use conventional HPLC instruments has resulted in intense basic studies of SPP technology, and widespread applications in many sciences. This report contains an overview of the SPP technology first developed in 2006 by Advanced Materials Technology, Inc., for sub-3-μm particles, then expanded into a family of SPP products with different particle sizes, pore sizes and other physical parameters. This approach was designed so that each particle of the family could be optimized for separating a particular group of compounds, usually based on solute size.
用于填充高效液相色谱（HPLC）柱的表面多孔颗粒（SPP）的出现，改变了许多从业者解决所需分离问题的方式。此类色谱柱的极高效率，再加上操作条件便利、背压适中以及能够使用传统HPLC仪器，引发了对SPP技术的深入基础研究，并在许多科学领域得到广泛应用。本报告概述了先进材料技术公司于2006年首次开发的用于亚3微米颗粒的SPP技术，随后扩展为一系列具有不同粒径、孔径和其他物理参数的SPP产品。这种方法的设计目的是使该系列中的每个颗粒都能针对特定的化合物组进行优化分离，通常是基于溶质大小。
