Chen Mo, Zhang Yuan, Que Xiao-Ting, Ding Ya, Yang Lin, Wen Ai-Dong, Hang Tai-Jun
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Department of Pharmacy, Xijing Hospital, Xi'an 710032, China.
J Pharm Anal. 2013 Dec;3(6):387-393. doi: 10.1016/j.jpha.2013.03.001. Epub 2013 Mar 20.
Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 µg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05-40 µg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA.
病毒灵是一种由肌苷与N,N-二甲基氨基-2-丙醇（DIP）的对乙酰氨基苯甲酸盐（PABA）组成的复方制剂。本研究旨在考察健康中国志愿者单次及多次口服病毒灵片后DIP和PABA的临床血浆药代动力学特性。所建立的用于测定血浆中DIP的LC/MS/MS方法线性范围为0.02 - 10 μg/mL，用于测定血浆中PABA的HPLC方法线性范围为0.05 - 40 μg/mL。单次口服0.5、1.0和2.0 g剂量时呈现线性药代动力学特征。未观察到DIP和PABA有明显的蓄积效应。
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