Ovalles José F, Gallignani Máximo, Brunetto María R, Rondón Rebeca A, Ayala Carlos
Departamento de Análisis y Control, Facultad de Farmacia y Bioanálisis, Universidad de Los Andes, Mérida 5101A, Venezuela.
Laboratorio de Espectroscopia Molecular, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101A, Venezuela.
J Pharm Anal. 2014 Apr;4(2):125-131. doi: 10.1016/j.jpha.2013.08.001. Epub 2013 Aug 14.
The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (>0.999, %RSD<2.0) in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.
本文报道了采用傅里叶变换红外导数光谱法在连续流动系统中对硫酸阿米卡星注射剂样品中的阿米卡星（AMK）进行定量测定。在未对样品进行任何预处理的情况下记录中红外光谱的傅里叶变换。发现在7.7 - 77.0 mg/mL范围内具有良好的线性校准（>0.999，相对标准偏差<2.0）。结果表明与制造商的数据具有良好的相关性，总体而言，所有结果均落在大多数硫酸阿米卡星药典专论的可接受限度内。
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