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柯西诺他汀（一种从 属中分离出的次生代谢产物）的抗菌和抗增殖前景

Antimicrobial and antiproliferative prospective of kosinostatin - a secondary metabolite isolated from sp.

作者信息

Rambabu Vinayagam, Suba Subramaniyan, Vijayakumar Suburamaniyan

机构信息

P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur, Tamil Nadu, India.

K.K Biotec Lab Service, Chennai, Tamil Nadu, India.

出版信息

J Pharm Anal. 2015 Dec;5(6):378-382. doi: 10.1016/j.jpha.2014.11.002. Epub 2014 Nov 29.

DOI:10.1016/j.jpha.2014.11.002
PMID:29403952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5762245/
Abstract

Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line (MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase (LDH) and glutathione (GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.

摘要

癌症是全球范围内的公共健康危害。本研究试图评估科西诺他汀对乳腺癌细胞系（MCF-7）的抗菌和抗癌潜力。通过MTT法以及乳酸脱氢酶（LDH）和谷胱甘肽（GSH）等细胞毒性试验，分析了科西诺他汀对MCF细胞系的抗癌和抗增殖活性。次生代谢产物科西诺他汀通过表达p53蛋白表现出其凋亡特性。总体而言，本研究获得的结果表明科西诺他汀具有强大的抗癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/c5dbc55d8c2d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/9acd1f44e1f5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/7f5d82d6bd7d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/9825377a7d60/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/162f4baeb537/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/93bcc475d6f2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/c5dbc55d8c2d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/9acd1f44e1f5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/7f5d82d6bd7d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/9825377a7d60/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/162f4baeb537/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/93bcc475d6f2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf5/5762245/c5dbc55d8c2d/gr6.jpg

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