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褐藻内生放线菌GRG1（KT235640）对尿路病原菌多重耐药菌株的分子特征及抗菌作用

Molecular characterization and antibacterial effect of endophytic actinomycetes sp. GRG1 (KT235640) from brown algae against MDR strains of uropathogens.

作者信息

Rajivgandhi Govindan, Vijayan Ramachandran, Kannan Marikani, Santhanakrishnan Malairaja, Manoharan Natesan

机构信息

Department of Marine Science, Bharathidasan University, Tiruchirappalli 24, Tamil Nadu, India.

School of Life Sciences, Jawaharlal Nehru University, New Delhi 67, India.

出版信息

Bioact Mater. 2016 Nov 25;1(2):140-150. doi: 10.1016/j.bioactmat.2016.11.002. eCollection 2016 Dec.

DOI:10.1016/j.bioactmat.2016.11.002
PMID:29744403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5883993/
Abstract

Our study is to evaluate the potential bioactive compound of sp. GRG1 (KT235640) and its antibacterial activity against multi drug resistant strains (MDRS) on urinary tract infections (UTIs). Two brown algae samples were collected and were subjected to isolation of endophytic actinomycetes. 100 strains of actinomycetes were isolated from algal samples based on observation of morphology and physiological characters. 40 strains were active in antagonistic activity against various clinical pathogens. Among the strains, 10 showed better antimicrobial activity against MDRS on UTIs. The secondary metabolite of sp. GRG1 (KT235640) has showed tremendous antibacterial activity against UTI pathogens compared to other strains. Influence of various growth parameters were used for synthesis of secondary metabolites, such as optimum pH 7, incubation time 5-7 days, temperature (30 °C), salinity (5%), fructose and mannitol as the suitable carbon and nitrogen sources. At 100 μg/ml concentration MIC of sp. GRG1 (KT235640) showed highest percentage of inhibition against sp 78-85% respectively.

摘要

我们的研究旨在评估GRG1菌株（KT235640）的潜在生物活性化合物及其对尿路感染（UTIs）多重耐药菌株（MDRS）的抗菌活性。采集了两个褐藻样本，并对其进行内生放线菌的分离。基于形态学和生理特征观察，从藻类样本中分离出100株放线菌。40株对各种临床病原体具有拮抗活性。其中，10株对UTIs的MDRS表现出更好的抗菌活性。与其他菌株相比，GRG1菌株（KT235640）的次生代谢产物对UTI病原体表现出巨大的抗菌活性。使用各种生长参数来合成次生代谢产物，如最适pH值7、培养时间5 - 7天、温度（30°C）、盐度（5%），果糖和甘露醇作为合适的碳源和氮源。在100μg/ml浓度下，GRG1菌株（KT235640）的最低抑菌浓度（MIC）分别对[具体菌株]显示出最高的抑制百分比，为78 - 85%。 （原文中“against sp ”表述不完整，这里根据语境推测补充了“[具体菌株]”）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/8cbd0fea3822/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/8a15af127a4f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/82796c3c0027/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/63d488fc2e01/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/202bf0d0cb1e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/3f69854891cf/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/5238990f1f20/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/ca2a13de4f10/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/ca695715ab03/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/0388bb369d7c/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/f86d9ff848b7/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/8cbd0fea3822/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/8a15af127a4f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/82796c3c0027/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/63d488fc2e01/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/202bf0d0cb1e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/3f69854891cf/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/5238990f1f20/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/ca2a13de4f10/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/ca695715ab03/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/0388bb369d7c/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/f86d9ff848b7/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eaf/5883993/8cbd0fea3822/figs4.jpg

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J Pharm Anal. 2015 Dec;5(6):378-382. doi: 10.1016/j.jpha.2014.11.002. Epub 2014 Nov 29.
2
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