van der Vorst Emiel P C, de Jong Renske J, Donners Marjo M P C
DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany.
Front Cardiovasc Med. 2018 Jan 22;5:2. doi: 10.3389/fcvm.2018.00002. eCollection 2018.
Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.
细胞外囊泡（EVs）已成为一种新型的细胞间通讯系统。通过携带生物活性脂质、微小RNA（miRNAs）和蛋白质，它们可以调节靶细胞的功能和表型。在炎症状态下，如心血管疾病患者，循环中的细胞外囊泡水平会升高，目前人们正在深入研究它们在动脉粥样硬化疾病发展中的功能作用。本综述将描述细胞外囊泡如何调节与血管炎症和动脉粥样硬化相关的血管细胞功能，特别强调细胞外囊泡相关的蛋白水解活性和相关效应蛋白的作用。此外，我们将讨论一些关键问题和挑战，尤其是基于细胞外囊泡的治疗方法所面临的问题和挑战。
