青少年和青年时期的身体活动与 BRCA1 和 BRCA2 突变携带者乳腺癌的风险。

Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.

机构信息

Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital rechts der Isar, Technical University of Munich (TUM), Munich, Germany.

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

出版信息

Breast Cancer Res Treat. 2018 Jun;169(3):561-571. doi: 10.1007/s10549-018-4694-1. Epub 2018 Feb 5.

DOI:10.1007/s10549-018-4694-1

PMID:29404807

Abstract

BACKGROUND

Physical activity is inversely associated with the risk of breast cancer among women in the general population. It is not clear whether or not physical activity is associated with the risk of BRCA-associated breast cancer.

METHODS

We conducted a case-control study of 443 matched pairs of BRCA mutation carriers to evaluate the association between physical activity and breast cancer risk. Moderate and vigorous physical activities at ages 12-13, ages 14-17, ages 18-22, ages 23-29 and ages 30-34 were determined using the Nurses' Health Study II Physical Activity Questionnaire. We estimated mean metabolic equivalent task hours/week for moderate, vigorous and total physical activities overall (ages 12-34), during adolescence (ages 12-17) and during early adulthood (ages 18-34). Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for total, moderate and strenuous recreational physical activities and breast cancer risk, by menopausal status.

RESULTS

Overall, there was no significant association between total physical activity and subsequent breast cancer risk (OR = 1.01, 95% CI 0.69-1.47; P-trend = 0.72). Moderate physical activity between ages 12-17 was associated with a 38% decreased risk of premenopausal breast cancer (OR = 0.62; 95% CI 0.40-0.96; P-trend = 0.01). We found no association between exercise and breast cancer diagnosed after menopause.

CONCLUSIONS

These findings suggest that early-life physical activity is associated with a reduced risk of premenopausal breast cancer among BRCA mutation carriers.

IMPACT

Future prospective analyses, complemented by mechanistic evidence, are warranted in this high-risk population.

摘要

背景

在普通人群中，身体活动与乳腺癌风险呈负相关。目前尚不清楚身体活动是否与 BRCA 相关乳腺癌的风险相关。

方法

我们对 443 对 BRCA 突变携带者进行了病例对照研究，以评估身体活动与乳腺癌风险之间的关系。使用护士健康研究 II 体力活动问卷确定 12-13 岁、14-17 岁、18-22 岁、23-29 岁和 30-34 岁时的适度和剧烈体力活动。我们估计了总体（12-34 岁）、青春期（12-17 岁）和成年早期（18-34 岁）期间适度、剧烈和总体力活动的平均代谢当量任务小时/周。使用逻辑回归分析估计绝经状态下总、适度和剧烈娱乐性体力活动与乳腺癌风险的比值比（OR）和 95%置信区间（CI）。

结果

总体而言，总体力活动与随后的乳腺癌风险之间没有显著关联（OR=1.01，95%CI 0.69-1.47；P 趋势=0.72）。12-17 岁期间的适度体力活动与绝经前乳腺癌风险降低 38%相关（OR=0.62；95%CI 0.40-0.96；P 趋势=0.01）。我们没有发现运动与绝经后诊断的乳腺癌之间的关联。