Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Cancer Res Commun. 2023 Nov 28;3(11):2420-2429. doi: 10.1158/2767-9764.CRC-23-0223.
UNLABELLED: In the general population, physical activity has been associated with a lower risk of several cancers; however, the evidence for ovarian cancer is not clear. It is suggested that early-life physical activity may differentially impact risk. Whether this is true among women at high risk due to a pathogenic variant (mutation) in the BRCA1 or BRCA2 genes has not been evaluated. Thus, we performed a matched case-control study to evaluate the association between adolescent and early-adulthood physical activity and ovarian cancer. BRCA mutation carriers who completed a research questionnaire on various exposures and incident disease and with data available on physical activity were eligible for inclusion. Self-reported activity at ages 12-13, 14-17, 18-22, 23-29, and 30-34 was used to calculate the average metabolic equivalent of task (MET)-hours/week for moderate, vigorous, and total physical activity during adolescence (ages 12-17) and early-adulthood (ages 18-34). Conditional logistic regression was used to estimate the OR and 95% confidence intervals (CI) of invasive ovarian cancer associated with physical activity. This study included 215 matched pairs (mean age = 57.3). There was no association between total physical activity during adolescence (ORhigh vs. low = 0.91; 95% CI: 0.61-1.36; Ptrend = 0.85), early-adulthood (ORhigh vs. low = 0.78; 95% CI: 0.51-1.20; Ptrend = 0.38) and overall (ORhigh vs. low = 0.81; 95% CI: 0.54-1.23; Ptrend = 0.56) and ovarian cancer. Findings were similar for moderate (Ptrend ≥ 0.25) and vigorous (Ptrend ≥ 0.57) activity. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, physical activity should continue to be encouraged to promote overall health. SIGNIFICANCE: In this matched case-control study, we observed no association between physical activity during adolescence or early-adulthood and subsequent risk of ovarian cancer. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, being active remains important to promote overall health and well-being.
未加标签：在普通人群中，身体活动与多种癌症的风险降低有关；然而，卵巢癌的证据并不明确。有研究表明，早年的身体活动可能会对风险产生不同的影响。由于 BRCA1 或 BRCA2 基因的致病性变异（突变），高危女性是否存在这种情况尚未得到评估。因此，我们进行了一项匹配病例对照研究，以评估青少年和成年早期身体活动与卵巢癌之间的关联。完成了关于各种暴露和发病情况的研究问卷且身体活动数据可用的 BRCA 突变携带者有资格入组。使用青少年（12-17 岁）和成年早期（18-34 岁）期间 12-13 岁、14-17 岁、18-22 岁、23-29 岁和 30-34 岁的自我报告活动来计算平均代谢当量任务（MET）小时/周的中度、剧烈和总身体活动量。条件逻辑回归用于估计与身体活动相关的侵袭性卵巢癌的比值比（OR）和 95%置信区间（CI）。这项研究包括 215 对匹配的病例对照（平均年龄=57.3 岁）。青少年时期（高 vs. 低=0.91；95%CI：0.61-1.36；Ptrend=0.85）、成年早期（高 vs. 低=0.78；95%CI：0.51-1.20；Ptrend=0.38）和总体（高 vs. 低=0.81；95%CI：0.54-1.23；Ptrend=0.56）身体活动与卵巢癌之间均无关联。中度（Ptrend≥0.25）和剧烈（Ptrend≥0.57）活动的结果相似。这些发现不能提供早期身体活动与 BRCA-卵巢癌之间存在关联的证据；然而，应继续鼓励身体活动以促进整体健康。
意义：在这项匹配病例对照研究中，我们观察到青少年或成年早期身体活动与随后卵巢癌风险之间没有关联。这些发现不能提供早期身体活动与 BRCA-卵巢癌之间存在关联的证据；然而，保持活跃对促进整体健康和幸福感仍然很重要。
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